Amoxicillin and Clavulanate – Medicine Details

Amoxicillin and Clavulanate

Also Known As / Brand Names

Amoxicillin and Clavulanate is a widely used combination antibiotic. Common brand names include:
  • Augmentin
  • Clavam
  • Curam
  • Co-amoxiclav
  • Amoclan
  • Moxclav
This combination is available in tablets, suspensions, and injectable forms.

Product Introduction

Amoxicillin and Clavulanate is a combination of two drugs: Amoxicillin, a penicillin-class antibiotic, and Clavulanate potassium, a beta-lactamase inhibitor. This combination works synergistically to treat bacterial infections by stopping bacterial growth and preventing resistance development.

Amoxicillin kills bacteria by inhibiting cell wall synthesis, while Clavulanate protects Amoxicillin from being broken down by beta-lactamase enzymes produced by resistant bacteria.

Uses of Amoxicillin and Clavulanate

  • Respiratory tract infections (sinusitis, pneumonia, bronchitis)
  • Urinary tract infections (UTIs)
  • Skin and soft tissue infections
  • Ear infections (otitis media)
  • Dental infections and abscesses
  • Bone and joint infections

Benefits of Amoxicillin and Clavulanate

This antibiotic combination is effective against a wide spectrum of bacteria, including those resistant to plain amoxicillin. Its dual mechanism enhances bacterial clearance and reduces the risk of treatment failure.

Its availability in various forms (tablets, oral suspension, injections) makes it suitable for all age groups and treatment settings, from mild infections to serious inpatient cases.

Side Effects of Amoxicillin and Clavulanate

Most side effects are mild and resolve on their own, but some may require medical attention. Common and rare side effects include:

  • Nausea, vomiting, diarrhea
  • Stomach pain or indigestion
  • Rash or itching
  • Yeast infections (oral or vaginal)
  • Headache or dizziness
  • Allergic reactions including hives or swelling
  • Liver enzyme changes or jaundice (rare)
  • Clostridioides difficile-associated diarrhea (severe but rare)

Safety Advice

Condition Advice
Pregnancy SAFE – Can be used during pregnancy if clearly needed. No evidence of risk in human studies.
Breastfeeding SAFE IF PRESCRIBED – Trace amounts may pass into breast milk, but generally safe under medical supervision.
Driving SAFE – Does not typically affect alertness or ability to drive. However, avoid driving if experiencing dizziness.
Kidney CAUTION – Dose adjustment may be needed in patients with kidney disease. Monitor renal function.
Liver CAUTION – Use with caution in liver disease. Liver function should be monitored during prolonged use.