Agamree
Also known as / Brand Names:
Agamree (generic name: Vamorolone)
Product Introduction:
Agamree is a newly approved corticosteroid-like medication that is used primarily for the treatment of Duchenne muscular dystrophy (DMD) in children aged 2 years and older. Unlike traditional corticosteroids, Agamree is designed to retain the anti-inflammatory benefits while reducing some of the adverse effects typically associated with long-term steroid use. It works by modifying inflammatory gene expression and improving muscle integrity, making it a novel and promising therapy in the management of DMD.
Uses of Agamree:
- Duchenne Muscular Dystrophy (DMD) in children aged 2 years and older
Benefits of Agamree:
- Helps in preserving muscle strength in patients with Duchenne Muscular Dystrophy
- May delay loss of ambulation (ability to walk)
- Reduced risk of common steroid side effects such as weight gain and bone weakening
- Improves quality of life and physical function in pediatric patients
Side Effects of Agamree:
- Vomiting
- Stomach pain
- Increased blood pressure
- Headache
- Behavioral changes
- Elevated liver enzymes
- Risk of infection (though lower than other corticosteroids)
How to Use:
Agamree should be taken as prescribed by a healthcare provider. It is available in oral suspension form and is usually given once daily. It should be taken with food to minimize gastrointestinal discomfort. Do not change the dose or discontinue the medicine without consulting the doctor.
Safety Advice:
| Condition | Advice |
|---|---|
| Pregnancy | CAUTION – Not approved for use in pregnant women. Limited data available. Use only if clearly needed under medical supervision. |
| Breastfeeding | CAUTION – It is unknown if Agamree passes into breast milk. Use only if prescribed by a doctor after assessing risks and benefits. |
| Driving | SAFE – Does not impair driving ability. However, monitor for dizziness or fatigue in individual cases. |
| Kidney | SAFE – No dose adjustment is usually needed. However, patients with severe kidney impairment should be monitored. |
| Liver | UNSAFE – Use with caution in patients with liver impairment. Liver enzymes should be monitored regularly during therapy. |
Precautions & Warnings:
- Regular liver function tests are recommended.
- May suppress immune function; avoid exposure to infections.
- Do not abruptly stop the medication; tapering may be needed to avoid withdrawal symptoms.
- Monitor blood pressure and glucose levels during prolonged use.
- Inform your doctor of all existing medical conditions and medications.
Interactions:
- Can interact with vaccines, reducing their effectiveness.
- May interact with antifungal medications, immunosuppressants, or other corticosteroids.
- Tell your doctor if you are using any herbal or over-the-counter supplements.
Storage:
Store Agamree oral suspension at room temperature between 20°C to 25°C. Keep the bottle tightly closed and out of reach of children. Do not use after the expiration date printed on the label.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Agamree only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.