Alendronate
Also known as / Brand Names:
Generic Name: Alendronate
Brand Names: Fosamax, Binosto, Adronil, Osteofos
Product Introduction:
Alendronate is a prescription medication used to treat or prevent osteoporosis in adults. It belongs to a class of drugs called bisphosphonates, which work by slowing down the process of bone breakdown, helping to maintain or increase bone density and reduce the risk of fractures. It is especially used in postmenopausal women and individuals taking corticosteroids who are at risk for bone loss.
Alendronate helps by binding to the bone surface and inhibiting osteoclasts—cells that break down bone. It is commonly taken once weekly or daily and must be taken on an empty stomach with water, remaining upright for at least 30 minutes afterward to prevent irritation of the esophagus.
Uses of Alendronate:
- Treatment and prevention of osteoporosis in postmenopausal women
- Osteoporosis in men
- Osteoporosis caused by long-term use of corticosteroids
- Paget’s disease of bone
Benefits of Alendronate:
- Increases bone mineral density
- Reduces risk of spine and hip fractures
- Slows progression of bone thinning in osteoporosis
- Effective in both men and women
- Convenient once-weekly or daily dosing options
Side Effects of Alendronate:
- Stomach upset or abdominal pain
- Heartburn or irritation of the esophagus
- Muscle or joint pain
- Nausea
- Constipation or diarrhea
- Rare: Osteonecrosis of the jaw (especially after dental procedures)
- Rare: Atypical femur fractures with long-term use
Safety Advice:
| Condition | Safety Advice |
|---|---|
| Pregnancy | Caution – Alendronate should only be used in pregnancy if clearly needed and prescribed by your doctor. |
| Breastfeeding | Caution – It is not known whether alendronate passes into breast milk. Consult your doctor before use. |
| Driving | Safe – Alendronate does not usually affect your ability to drive or operate machinery. |
| Kidney | Caution – Not recommended in patients with severe kidney impairment (creatinine clearance < 35 mL/min). |
| Liver | Safe – No dose adjustment is typically needed for liver conditions. |
How to Use Alendronate:
Take Alendronate exactly as prescribed. It must be taken first thing in the morning, at least 30 minutes before any food, drink (except plain water), or other medications. Swallow the tablet with a full glass (6–8 oz) of plain water while sitting or standing. Do not lie down or recline for at least 30 minutes after taking the medication to prevent esophageal irritation.
Interactions:
Inform your healthcare provider about all medications you take. Notable interactions include:
- Calcium or iron supplements (may interfere with absorption)
- Antacids (should be taken at a different time)
- Aspirin or NSAIDs (increased risk of stomach irritation)
Storage Instructions:
Store at room temperature between 20°C to 25°C (68°F to 77°F). Keep the medicine in its original container, tightly closed, away from moisture and heat. Keep out of reach of children.
Important Reminder:
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Alendronate only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.